Grand Theft Auto, Black & White 2, Ghost Recon
Here's a curious one. The game installs and runs just fine. There are no visual or audio glitches, performance is just fine, and the game even shows up in the Games Explorer. That's the curious part.
The title of the game in Games Explorer is Grand Theft Auto: San Andreas ["AO" Version], meaning that this is one of the original releases of the game that could be modified with the controversial "Hot Coffee" mod that caused the ESRB to retroactively change the rating to Adults Only. But the actual rating in the system is still Mature, as you can see from the screenshot below.
Beyond this one error in the rating, the game is good to go on Vista.
Black & White 2
This game is another performance hog, at least when all the graphics details are turned up. We were surprised how well it ran at 1600x1200 (with no anti-aliasing). It feels about as smooth as it does with a similarly configured machine running Windows XP. We didn't have any problems playing on several different worlds or playing around with all the game options. If they add Black & White 2 to the Games Explorer, we'll call this one ready to roll on Vista.
Ghost Recon: Advanced Warfighter
During installation, the game installs the PhysX driver from Ageia, even if you don't have a PhysX hardware card. At this point, you'll see a warning that the PhysX driver won't support hardware acceleration under anything but Windows XP, but PhysX software support will still function.
After that warning, the game works just fine under Vista, both single and multiplayer (once you let the game through the Windows firewall, just as you would under WinXP with Service Pack 2). Performance was acceptable, and all games modes worked. All the graphics options seemed to work fine, even windowed mode.